Posintro™ 

Posintro™  is a self-assembling, unique nano-particle that was developed and patented by Nordic Vaccine from the earlier ISCOMs = Immune Stimulating COMplexes. The resulting Posintro™ platform is one of the most efficient delivery and adjuvant systems known today.

The basic components are saponin derived from the Quillaja Saponaria tree, phosphatidyl-choline and cholesterol.

Given the right conditions, these components assemble into a cage-like structure with an average diameter of 40-50nm, as shown in the model above and the electron microscopy picture to the right. 

The structure and composition of Posintro™ allow the immunogen to be bound to the particle by a multitude of different mechanisms, e.g. electrostatic interaction by charge modification, incorporation of chelating groups or direct binding.

Significant features of the Posintro™ system:

• One of the most efficient delivery and adjuvant systems known today.

• Chemical functionality can be tailor-made for various types of antigens 

• Protect the immunogen(s) against in vivo degradation

• Facilitate both antibody- and cellular (cytolytic/Th1) immune responses

• The particles are stable at RT and can be freeze-dried 

• Facilitates transport over skin and mucosal membranes